In the This American Life blog post which is a list of the staff's favorite lists of other sites' favorite This American Life episodes, Ira links to a 2005 AskMeFi thread in which MetaFilter members named their favorites. Notably, there was remarkable consensus among lists of that vintage and the lists that were published this month to observe the show's 500th episode. I'm fairly surprised there hasn't been a more recent thread along those lines.
In forever searching for a bridge to close the gap between those who want more restrictive MeFi Guidelines and those who want less, I've recently found myself comparing recent MeFi discussions to how TAL submissions get on the show. Or Ira Glass' basic Radio Principles. What can MetaFilter learn from This American Life?